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Michael F Jarvis Selected Research

2- (3,4- difluorophenyl)- 4- (3- hydroxy- 3- methylbutoxy)- 5- (4- methanesulfonylphenyl)- 2H- pyridazin- 3- one

12/2004ABT-963 [2-(3,4-difluoro-phenyl)-4-(3-hydroxy-3-methyl-butoxy)-5-(4-methanesulfonyl-phenyl)-2H-pyridazin-3-one], a highly potent and selective disubstituted pyridazinone cyclooxgenase-2 inhibitor.

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Michael F Jarvis Research Topics

Disease

44Pain (Aches)
01/2021 - 03/2002
27Hyperalgesia
06/2014 - 03/2002
25Neuralgia (Stump Neuralgia)
06/2014 - 03/2002
11Chronic Pain
06/2014 - 12/2002
10Inflammation (Inflammations)
01/2021 - 10/2002
5Postoperative Pain
05/2007 - 12/2002
4Wounds and Injuries (Trauma)
01/2019 - 03/2002
3Epilepsy (Aura)
01/2021 - 01/2005
3Visceral Pain
08/2006 - 03/2002
2Intractable Pain
12/2014 - 12/2012
2Osteoarthritis
07/2013 - 05/2011
2Bone Neoplasms (Bone Cancer)
08/2012 - 03/2009
2Acute Pain
02/2006 - 12/2002
2Edema (Dropsy)
12/2004 - 03/2002
1HIV Infections (HIV Infection)
12/2021
1Nervous System Diseases (Neurological Disorders)
02/2013
1Neoplasms (Cancer)
08/2012
1Acute Monocytic Leukemia (Acute Monoblastic Leukemia)
06/2012
1Hypersensitivity (Allergy)
02/2012
1Arthralgia (Joint Pain)
05/2011
1Nociceptive Pain
01/2010
1Mood Disorders (Mood Disorder)
03/2009
1Hyperthermia
03/2009
1Peritonitis
05/2008

Drug/Important Bio-Agent (IBA)

16Freund's AdjuvantIBA
06/2014 - 12/2002
13Analgesics (Analgesic Drugs)IBA
04/2014 - 03/2002
9Capsaicin (Zostrix)FDA Link
02/2012 - 10/2003
8CarrageenanIBA
06/2014 - 03/2002
8A-317491IBA
08/2012 - 12/2002
7Sodium Channels (Sodium Channel)IBA
11/2010 - 07/2006
6TRPV1 receptorIBA
03/2012 - 10/2003
5Pharmaceutical PreparationsIBA
01/2021 - 02/2008
5Adenosine Triphosphate (ATP)IBA
02/2012 - 08/2003
4beta-apocarotenoid-14',13'-dioxygenase (ADO)IBA
01/2019 - 03/2002
4Purinergic P2X7 ReceptorsIBA
06/2012 - 12/2006
4Sodium Channel BlockersIBA
09/2010 - 05/2007
4LigandsIBA
03/2009 - 08/2006
4Antisense OligonucleotidesIBA
02/2008 - 09/2002
4NucleotidesIBA
08/2006 - 12/2002
3Iodoacetic AcidIBA
02/2018 - 05/2011
3AcidsIBA
08/2012 - 07/2005
3A-889425IBA
03/2012 - 12/2008
3Neurotransmitter Agents (Neurotransmitter)IBA
02/2012 - 10/2002
3Biological ProductsIBA
11/2010 - 02/2008
3A 803467IBA
03/2009 - 05/2007
31- isoquinolin- 5- yl- 3- (4- trifluoromethyl- benzyl)- ureaIBA
03/2009 - 07/2005
3Formaldehyde (Formol)FDA Link
05/2007 - 03/2002
2NucleosidesIBA
01/2019 - 10/2002
2Adenosine (Adenocard)FDA LinkGeneric
01/2019 - 10/2002
24- chloro- 2- fluoro- N- (2- fluorophenyl)- 5- (hexahydropyrrolo(1,2- a)pyrazin- 2(1H)- ylcarbonyl)benzenesulfonamideIBA
06/2015 - 06/2014
2ziconotide (Prialt)FDA Link
12/2014 - 12/2012
2N2- methyl- N- ((2- (4- (trifluoromethyl)phenyl)octahydrocyclopenta(c)pyrrol- 4- yl)leucinamideIBA
04/2014 - 01/2014
2Mitogen-Activated Protein KinasesIBA
02/2014 - 05/2011
2SodiumIBA
08/2012 - 07/2006
2Ligand-Gated Ion ChannelsIBA
01/2010 - 03/2009
2Voltage-Gated Sodium ChannelsIBA
04/2009 - 02/2008
2furanIBA
06/2008 - 03/2008
2Proteins (Proteins, Gene)FDA Link
05/2007 - 09/2002
2Vincristine (Oncovin)FDA LinkGeneric
12/2006 - 07/2006
2Naloxone (Narcan)FDA LinkGeneric
09/2005 - 03/2002
2Adenosine KinaseIBA
10/2002 - 03/2002
1LopinavirFDA Link
12/2021
1Ritonavir (Norvir)FDA Link
12/2021
1Antiviral Agents (Antivirals)IBA
12/2021
12-methylcyclopentadienyl manganese tricarbonyl (MMT)IBA
02/2018
1PlasticsIBA
02/2018
1T-Type Calcium Channels (T-Type Calcium Channel)IBA
06/2014
1Biomarkers (Surrogate Marker)IBA
04/2014
1Mitogen-Activated Protein Kinase 3IBA
04/2014
1Transcription Factors (Transcription Factor)IBA
02/2014
1Cyclic AMP Response Element-Binding Protein (Cyclic AMP-Responsive DNA-Binding Protein)IBA
02/2014
1Phosphotransferases (Kinase)IBA
02/2014
1N-Type Calcium Channels (N-Type Calcium Channel)IBA
09/2013
1Peptides (Polypeptides)IBA
12/2012
1SaltsIBA
08/2012
1Purinergic P2X3 ReceptorsIBA
08/2012
1A-1048400IBA
02/2012
1PyrazinesIBA
11/2010
15- (4- butoxy- 3- chlorophenyl)- N- ((2- morpholinopyridin- 3- yl)methyl)nicotinamideIBA
09/2010
1Purinergic Receptors (Receptors, Purine)IBA
01/2010
1A-839977IBA
12/2009
1dicyandiamido (cyanoguanidine)IBA
05/2009
1Protein Isoforms (Isoforms)IBA
04/2009
1CytokinesIBA
03/2009
1LipidsIBA
03/2009
1ABT 102IBA
03/2009
1Ion Channels (Ion Channel)IBA
03/2009
1PyrrolidinesIBA
09/2008
1arachidonyl dopamineIBA
09/2008
1CationsIBA
09/2008
1PiperazineIBA
06/2008
1Mexiletine (Mexitil)FDA LinkGeneric
06/2008
1Lamotrigine (Lamictal)FDA LinkGeneric
06/2008
1ZymosanIBA
05/2008

Therapy/Procedure

12Ligation
01/2014 - 03/2002
8Oral Administration
06/2015 - 12/2004
3Therapeutics
12/2021 - 04/2009
2Injections
01/2006 - 12/2003
1Intra-Articular Injections
05/2011
1Analgesia
02/2008